Reduced Renal Colonization and Enhanced Protection by Leptospiral Factor H Binding Proteins as a Multisubunit Vaccine against Leptospirosis in Hamsters

Reduced Renal Colonization and Enhanced Protection by Leptospiral Factor H Binding Proteins as a Multisubunit Vaccine against Leptospirosis in Hamsters

Subunit vaccines conferring complete protection against leptospirosis are not currently available. The interactions of factor H binding proteins (FHBPs) on pathogenic leptospires and host factor H are crucial for immune evasion by inhibition of complement-mediated killing. The inhibition of these in...

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Bibliographic Details
Main Authors: Teerasit Techawiwattanaboon, Christophe Barnier-Quer, Tanapat Palaga, Alain Jacquet, Nicolas Collin, Noppadon Sangjun, Pat Komanee, Surapon Piboonpocanun, Kanitha Patarakul
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Vaccines
Subjects:
leptospirosis
<i>Leptospira</i>
factor H binding protein
multisubunit vaccine
neutral liposome
MPL
QS21
Online Access:https://www.mdpi.com/2076-393X/7/3/95

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https://www.mdpi.com/2076-393X/7/3/95

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