A nonlinear and time-dependent leak current in the presence of calcium fluoride patch-clamp seal enhancer [version 2; peer review: 1 approved, 3 approved with reservations]
Automated patch-clamp platforms are widely used and vital tools in both academia and industry to enable high-throughput studies such as drug screening. A leak current to ground occurs whenever the seal between a pipette and cell (or internal solution and cell in high-throughput machines) is not perf...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wellcome
2021-11-01
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| Series: | Wellcome Open Research |
| Online Access: | https://wellcomeopenresearch.org/articles/5-152/v2 |