Mode of administration influences plasma levels of active Centella asiatica compounds in 5xFAD mice while markers of neuroinflammation remain unaltered

Mode of administration influences plasma levels of active Centella asiatica compounds in 5xFAD mice while markers of neuroinflammation remain unaltered

IntroductionA water extract of Centella asiatica (L.) Urban [Apiaceae] (CAW) has demonstrated cognitive-enhancing effects in mouse models of Alzheimer’s disease and aging, the magnitude of which is influenced by whether CAW is delivered in the drinking water or the diet. These cognitive benefits are...

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Bibliographic Details
Main Authors: Alex B. Speers, Kirsten M. Wright, Mikah S. Brandes, Nareg Kedjejian, Donald G. Matthews, Maya Caruso, Christopher J. Harris, Seiji Koike, Thuan Nguyen, Joseph F. Quinn, Amala Soumyanath, Nora E. Gray
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Neuroscience
Subjects:
Centella asiatica
Alzheimer’s disease
neuroinflammation
5xFAD
triterpenes
caffeoylquinic acids
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2024.1277626/full

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https://www.frontiersin.org/articles/10.3389/fnins.2024.1277626/full

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