Myalgic Encephalomyelitis/Chronic Fatigue Syndrome as a Hyper-Regulated Immune System Driven by an Interplay Between Regulatory T Cells and Chronic Human Herpesvirus Infections

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome as a Hyper-Regulated Immune System Driven by an Interplay Between Regulatory T Cells and Chronic Human Herpesvirus Infections

Autoimmunity and chronic viral infections are recurrent clinical observations in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a complex disease with an unknown cause. Given these observations, the regulatory CD4+ T cells (Tregs) show promise to be good candidates for the underlying p...

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Bibliographic Details
Main Authors: Nuno Sepúlveda, Jorge Carneiro, Eliana Lacerda, Luis Nacul
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
viral infection
autoimmunity
immunological theory
immunological tolerance and regulation
hypothesis
mathematical modeling
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02684/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02684/full

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