LCAT protects against Lipoprotein‐X formation in a murine model of drug‐induced intrahepatic cholestasis

LCAT protects against Lipoprotein‐X formation in a murine model of drug‐induced intrahepatic cholestasis

Abstract Familial lecithin:cholesterol acyltransferase (LCAT) deficiency (FLD) is a rare genetic disease characterized by low HDL‐C levels, low plasma cholesterol esterification, and the formation of Lipoprotein‐X (Lp‐X), an abnormal cholesterol‐rich lipoprotein particle. LCAT deficiency causes corn...

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Bibliographic Details
Main Authors: Marcelo J. A. Amar, Lita A. Freeman, Takafumi Nishida, Maureen L. Sampson, Milton Pryor, Boris L. Vaisman, Edward B. Neufeld, Sotirios K. Karathanasis, Alan T. Remaley
Format: Article
Language:English
Published: Wiley 2020-02-01
Series:Pharmacology Research & Perspectives
Subjects:
cholesterol acyltransferase
cholesterol acyltransferase deficiency
deficient mouse
Familial lecithin
intrahepatic cholestasis
LCAT transgenic mouse
Online Access:https://doi.org/10.1002/prp2.554

Internet

https://doi.org/10.1002/prp2.554

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