Targeting cancers and metabolic disorders: The prospects of combining HDAC8 inhibitor and activator
Histone deacetylase-8 (HDAC8) is a unique member of class I Zn2+-dependent metalloenzyme of the classical histone deacetylases owing to its highly structural and kinetic characterization. Of interest, the diminution in the expression level of HDAC8 and or the impaired activity of the enzyme has been...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | European Journal of Medicinal Chemistry Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772417422000693 |