Characterization and Monitoring of Antigen-Responsive T Cell Clones Using T Cell Receptor Gene Expression Analysis

Characterization and Monitoring of Antigen-Responsive T Cell Clones Using T Cell Receptor Gene Expression Analysis

High-throughput T-cell receptor repertoire sequencing constitutes a powerful tool to study T cell responses at the clonal level. However, it does not give information on the functional phenotype of the responding clones and lacks a statistical framework for quantitative evaluation. To overcome this,...

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Bibliographic Details
Main Authors: Sabrina Pollastro, Marie de Bourayne, Giulia Balzaretti, Aldo Jongejan, Barbera D. C. van Schaik, Ilse T. G. Niewold, Antoine H. C. van Kampen, Bernard Maillère, Niek de Vries
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
T-cell receptor
adaptive immune receptor repertoire
T cell responses
next generation sequencing
bioinformatics
immunoinformatics
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.609624/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.609624/full

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