Decision-Making in Cascade Complexes Harboring crRNAs of Altered Length

Decision-Making in Cascade Complexes Harboring crRNAs of Altered Length

Summary: The multi-subunit type I CRISPR-Cas surveillance complex Cascade uses its crRNA to recognize dsDNA targets. Recognition involves DNA unwinding and base-pairing between the crRNA spacer region and a complementary DNA strand, resulting in formation of an R-loop structure. The modular Cascade...

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Bibliographic Details
Main Authors: Inga Songailiene, Marius Rutkauskas, Tomas Sinkunas, Elena Manakova, Sabine Wittig, Carla Schmidt, Virginijus Siksnys, Ralf Seidel
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719310733

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http://www.sciencedirect.com/science/article/pii/S2211124719310733

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