The Interplay between Intracellular Iron Homeostasis and Neuroinflammation in Neurodegenerative Diseases

The Interplay between Intracellular Iron Homeostasis and Neuroinflammation in Neurodegenerative Diseases

Iron is essential for life. Many enzymes require iron for appropriate function. However, dysregulation of intracellular iron homeostasis produces excessive reactive oxygen species (ROS) via the Fenton reaction and causes devastating effects on cells, leading to ferroptosis, an iron-dependent cell de...

Full description

Bibliographic Details
Main Authors: Jaewang Lee, Dong-Hoon Hyun
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Antioxidants
Subjects:
intracellular iron homeostasis
neuroinflammation
neurodegenerative diseases
Nrf2
NF-κB
ferroptosis
Online Access:https://www.mdpi.com/2076-3921/12/4/918

Internet

https://www.mdpi.com/2076-3921/12/4/918

Similar Items