Prediction of severe CRS and determination of biomarkers in B cell-acute lymphoblastic leukemia treated with CAR-T cells

Prediction of severe CRS and determination of biomarkers in B cell-acute lymphoblastic leukemia treated with CAR-T cells

IntroductionCAR-T cell therapy is a novel approach in the treatment of hematological tumors. However, it is associated with life-threatening side effects, such as the severe cytokine release syndrome (sCRS). Therefore, predicting the occurrence and development of sCRS is of great significance for cl...

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Bibliographic Details
Main Authors: Zhenyu Wei, Jiayu Xu, Chengkui Zhao, Min Zhang, Nan Xu, Liqing Kang, Xiaoyan Lou, Lei Yu, Weixing Feng
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
CAR-T cell therapy
cytokine release syndrome (CRS)
biomarker
prediction
decision tree
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1273507/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1273507/full

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