Widespread amyloidogenicity potential of multiple myeloma patient-derived immunoglobulin light chains

Widespread amyloidogenicity potential of multiple myeloma patient-derived immunoglobulin light chains

Abstract Background In a range of human disorders such as multiple myeloma (MM), immunoglobulin light chains (IgLCs) can be produced at very high concentrations. This can lead to pathological aggregation and deposition of IgLCs in different tissues, which in turn leads to severe and potentially fata...

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Main Authors: Rebecca Sternke-Hoffmann, Thomas Pauly, Rasmus K. Norrild, Jan Hansen, Florian Tucholski, Magnus Haraldson Høie, Paolo Marcatili, Mathieu Dupré, Magalie Duchateau, Martial Rey, Christian Malosse, Sabine Metzger, Amelie Boquoi, Florian Platten, Stefan U. Egelhaaf, Julia Chamot-Rooke, Roland Fenk, Luitgard Nagel-Steger, Rainer Haas, Alexander K. Buell
Format: Article
Language:English
Published: BMC 2023-02-01
Series:BMC Biology
Subjects:
Amyloid
Immunoglobulin
Multiple myeloma
AL amyloidosis
Light chain
Multiparametric approach
Online Access:https://doi.org/10.1186/s12915-022-01506-w

Internet

https://doi.org/10.1186/s12915-022-01506-w

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