Molecular mechanisms of developmental pathways in neurological disorders: a pharmacological and therapeutic review
Developmental signalling pathways such as Wnt/β-catenin, Notch and Sonic hedgehog play a central role in nearly all the stages of neuronal development. The term ‘embryonic’ might appear to be a misnomer to several people because these pathways are functional during the early stages of embryonic deve...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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The Royal Society
2022-03-01
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| Series: | Open Biology |
| Subjects: | |
| Online Access: | https://royalsocietypublishing.org/doi/10.1098/rsob.210289 |
| _version_ | 1797837588647641088 |
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| author | Niraj Kumar Jha Wei-Chih Chen Sanjay Kumar Rajni Dubey Lung-Wen Tsai Rohan Kar Saurabh Kumar Jha Piyush Kumar Gupta Ankur Sharma Rohit Gundamaraju Kumud Pant Shalini Mani Sandeep Kumar Singh Ricardo B. Maccioni Tirtharaj Datta Sachin Kumar Singh Gaurav Gupta Parteek Prasher Kamal Dua Abhijit Dey Charu Sharma Yasir Hayat Mughal Janne Ruokolainen Kavindra Kumar Kesari Shreesh Ojha |
| author_facet | Niraj Kumar Jha Wei-Chih Chen Sanjay Kumar Rajni Dubey Lung-Wen Tsai Rohan Kar Saurabh Kumar Jha Piyush Kumar Gupta Ankur Sharma Rohit Gundamaraju Kumud Pant Shalini Mani Sandeep Kumar Singh Ricardo B. Maccioni Tirtharaj Datta Sachin Kumar Singh Gaurav Gupta Parteek Prasher Kamal Dua Abhijit Dey Charu Sharma Yasir Hayat Mughal Janne Ruokolainen Kavindra Kumar Kesari Shreesh Ojha |
| author_sort | Niraj Kumar Jha |
| collection | DOAJ |
| description | Developmental signalling pathways such as Wnt/β-catenin, Notch and Sonic hedgehog play a central role in nearly all the stages of neuronal development. The term ‘embryonic’ might appear to be a misnomer to several people because these pathways are functional during the early stages of embryonic development and adulthood, albeit to a certain degree. Therefore, any aberration in these pathways or their associated components may contribute towards a detrimental outcome in the form of neurological disorders such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and stroke. In the last decade, researchers have extensively studied these pathways to decipher disease-related interactions, which can be used as therapeutic targets to improve outcomes in patients with neurological abnormalities. However, a lot remains to be understood in this domain. Nevertheless, there is strong evidence supporting the fact that embryonic signalling is indeed a crucial mechanism as is manifested by its role in driving memory loss, motor impairments and many other processes after brain trauma. In this review, we explore the key roles of three embryonic pathways in modulating a range of homeostatic processes such as maintaining blood–brain barrier integrity, mitochondrial dynamics and neuroinflammation. In addition, we extensively investigated the effect of these pathways in driving the pathophysiology of a range of disorders such as Alzheimer's, Parkinson's and diabetic neuropathy. The concluding section of the review is dedicated to neurotherapeutics, wherein we identify and list a range of biological molecules and compounds that have shown enormous potential in improving prognosis in patients with these disorders. |
| first_indexed | 2024-04-09T15:28:13Z |
| format | Article |
| id | doaj.art-a555f0644d414f57ab24b50405a146dd |
| institution | Directory Open Access Journal |
| issn | 2046-2441 |
| language | English |
| last_indexed | 2024-04-09T15:28:13Z |
| publishDate | 2022-03-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Open Biology |
| spelling | doaj.art-a555f0644d414f57ab24b50405a146dd2023-04-28T11:07:58ZengThe Royal SocietyOpen Biology2046-24412022-03-0112310.1098/rsob.210289Molecular mechanisms of developmental pathways in neurological disorders: a pharmacological and therapeutic reviewNiraj Kumar Jha0Wei-Chih Chen1Sanjay Kumar2Rajni Dubey3Lung-Wen Tsai4Rohan Kar5Saurabh Kumar Jha6Piyush Kumar Gupta7Ankur Sharma8Rohit Gundamaraju9Kumud Pant10Shalini Mani11Sandeep Kumar Singh12Ricardo B. Maccioni13Tirtharaj Datta14Sachin Kumar Singh15Gaurav Gupta16Parteek Prasher17Kamal Dua18Abhijit Dey19Charu Sharma20Yasir Hayat Mughal21Janne Ruokolainen22Kavindra Kumar Kesari23Shreesh Ojha24Department of Biotechnology, School of Engineering and Technology (SET), Sharda University, Greater Noida, Uttar Pradesh 201310, IndiaDivision of General Surgery, Department of Surgery, Taipei Medical University Hospital, Taipei 11031, TaiwanDepartment of Life Science, School of Basic Science and Research, Sharda University, Greater Noida, Uttar Pradesh 201310, IndiaDepartment of Medicine Research, Taipei Medical University Hospital, Taipei 11031, TaiwanDepartment of Medicine Research, Taipei Medical University Hospital, Taipei 11031, TaiwanIndian Institute of Management Ahmedabad (IIMA), Gujarat 380015, IndiaDepartment of Biotechnology, School of Engineering and Technology (SET), Sharda University, Greater Noida, Uttar Pradesh 201310, IndiaDepartment of Life Science, School of Basic Science and Research, Sharda University, Greater Noida, Uttar Pradesh 201310, IndiaDepartment of Life Science, School of Basic Science and Research, Sharda University, Greater Noida, Uttar Pradesh 201310, IndiaER Stress and Mucosal Immunology Laboratory, School of Health Sciences, University of Tasmania, Launceston, Tasmania 7248, AustraliaDepartment of Biotechnology, Graphic Era deemed to be University Dehradun Uttarakhand, 248002 Dehradun, IndiaDepartment of Biotechnology, Jaypee Institute of Information Technology, A-10, Sector 62, Noida, Uttar Pradesh 201301, IndiaIndian Scientific Education and Technology Foundation, Lucknow 226002, IndiaLaboratory of Neurosciences and Functional Medicine, International Center for Biomedicine (ICC) and Faculty of Sciences, University of Chile, Santiago de Chile, ChileDepartment of Biotechnology, School of Engineering and Technology (SET), Sharda University, Greater Noida, Uttar Pradesh 201310, IndiaSchool of Pharmaceutical Sciences, Lovely Professional University, Phagwara 144411, Punjab, IndiaDepartment of Pharmacology, School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, 302017 Jagatpura, Jaipur, IndiaDepartment of Chemistry, University of Petroleum and Energy Studies, Dehradun 248007, Uttarakhand, IndiaDiscipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, New South Wales 2007, AustraliaDepartment of Life Sciences, Presidency University, 86/1 College Street, Kolkata 700073, IndiaDepartment of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, PO Box 15551, Al Ain, United Arab EmiratesDepartment of Health Administration, College of Public Health and Health Informatics, Qassim University, Buraidah, Saudi ArabiaDepartment of Applied Physics, School of Science, andDepartment of Applied Physics, School of Science, andDepartment of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, PO Box 15551, Al Ain, United Arab EmiratesDevelopmental signalling pathways such as Wnt/β-catenin, Notch and Sonic hedgehog play a central role in nearly all the stages of neuronal development. The term ‘embryonic’ might appear to be a misnomer to several people because these pathways are functional during the early stages of embryonic development and adulthood, albeit to a certain degree. Therefore, any aberration in these pathways or their associated components may contribute towards a detrimental outcome in the form of neurological disorders such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and stroke. In the last decade, researchers have extensively studied these pathways to decipher disease-related interactions, which can be used as therapeutic targets to improve outcomes in patients with neurological abnormalities. However, a lot remains to be understood in this domain. Nevertheless, there is strong evidence supporting the fact that embryonic signalling is indeed a crucial mechanism as is manifested by its role in driving memory loss, motor impairments and many other processes after brain trauma. In this review, we explore the key roles of three embryonic pathways in modulating a range of homeostatic processes such as maintaining blood–brain barrier integrity, mitochondrial dynamics and neuroinflammation. In addition, we extensively investigated the effect of these pathways in driving the pathophysiology of a range of disorders such as Alzheimer's, Parkinson's and diabetic neuropathy. The concluding section of the review is dedicated to neurotherapeutics, wherein we identify and list a range of biological molecules and compounds that have shown enormous potential in improving prognosis in patients with these disorders.https://royalsocietypublishing.org/doi/10.1098/rsob.210289Wnt/β-cateninNotchSonic hedgehogCNSneurodegenerationneurotherapeutics |
| spellingShingle | Niraj Kumar Jha Wei-Chih Chen Sanjay Kumar Rajni Dubey Lung-Wen Tsai Rohan Kar Saurabh Kumar Jha Piyush Kumar Gupta Ankur Sharma Rohit Gundamaraju Kumud Pant Shalini Mani Sandeep Kumar Singh Ricardo B. Maccioni Tirtharaj Datta Sachin Kumar Singh Gaurav Gupta Parteek Prasher Kamal Dua Abhijit Dey Charu Sharma Yasir Hayat Mughal Janne Ruokolainen Kavindra Kumar Kesari Shreesh Ojha Molecular mechanisms of developmental pathways in neurological disorders: a pharmacological and therapeutic review Open Biology Wnt/β-catenin Notch Sonic hedgehog CNS neurodegeneration neurotherapeutics |
| title | Molecular mechanisms of developmental pathways in neurological disorders: a pharmacological and therapeutic review |
| title_full | Molecular mechanisms of developmental pathways in neurological disorders: a pharmacological and therapeutic review |
| title_fullStr | Molecular mechanisms of developmental pathways in neurological disorders: a pharmacological and therapeutic review |
| title_full_unstemmed | Molecular mechanisms of developmental pathways in neurological disorders: a pharmacological and therapeutic review |
| title_short | Molecular mechanisms of developmental pathways in neurological disorders: a pharmacological and therapeutic review |
| title_sort | molecular mechanisms of developmental pathways in neurological disorders a pharmacological and therapeutic review |
| topic | Wnt/β-catenin Notch Sonic hedgehog CNS neurodegeneration neurotherapeutics |
| url | https://royalsocietypublishing.org/doi/10.1098/rsob.210289 |
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