PARP1 expression in soft tissue sarcomas is a poor‐prognosis factor and a new potential therapeutic target

PARP1 expression in soft tissue sarcomas is a poor‐prognosis factor and a new potential therapeutic target

Soft tissue sarcomas (STSs) are aggressive tumors with few efficient systemic therapies. Poly(ADP‐ribose) polymerase‐1 (PARP1) inhibitors represent an emerging therapeutic option in tumors with genomic instability. The genomics of STSs is complex in more than half of cases, suggesting a high level o...

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Bibliographic Details
Main Authors: François Bertucci, Pascal Finetti, Audrey Monneur, Delphine Perrot, Christine Chevreau, Axel Le Cesne, Jean‐Yves Blay, Olivier Mir, Daniel Birnbaum
Format: Article
Language:English
Published: Wiley 2019-07-01
Series:Molecular Oncology
Subjects:
PARP inhibitor
PARP1 expression
prognosis
soft tissue sarcoma
survival
Online Access:https://doi.org/10.1002/1878-0261.12522

Internet

https://doi.org/10.1002/1878-0261.12522

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