Putative critical quality attribute matrix identifies mesenchymal stromal cells with potent immunomodulatory and angiogenic “fitness” ranges in response to culture process parameters

Putative critical quality attribute matrix identifies mesenchymal stromal cells with potent immunomodulatory and angiogenic “fitness” ranges in response to culture process parameters

Adipose-derived mesenchymal stromal cells (MSC(AT)) display immunomodulatory and angiogenic properties, but an improved understanding of quantitative critical quality attributes (CQAs) that inform basal MSC(AT) fitness ranges for immunomodulatory and/or angiogenic applications is urgently needed for...

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Bibliographic Details
Main Authors: Kevin P. Robb, Julie Audet, Rajiv Gandhi, Sowmya Viswanathan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
mesenchymal stromal cell
immunomodulation
angiogenesis
critical quality attribute
donor heterogeneity
3D suspension cultures
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.972095/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.972095/full

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