Prolonged warm ischemia time increases mitogen-activated protein kinase activity and decreases perfusate cytokine levels in ex vivo rat liver machine perfusion

Prolonged warm ischemia time increases mitogen-activated protein kinase activity and decreases perfusate cytokine levels in ex vivo rat liver machine perfusion

IntroductionMachine perfusion is increasingly being utilized in liver transplantation in lieu of traditional cold static organ preservation. Nevertheless, better understanding of the molecular mechanisms underlying the ischemia-reperfusion injury (IRI) during ex vivo perfusion is necessary to improv...

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Bibliographic Details
Main Authors: Joohyun Kim, Seung-Keun Hong, Yongqiang Yang, Alice Lee, Karin M. Hoffmeister, Benjamin N. Gantner, Jong-In Park
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Transplantation
Subjects:
liver viability
warm ischemia time
cytokine
chemokine
machine perfusion
Online Access:https://www.frontiersin.org/articles/10.3389/frtra.2023.1215182/full

Internet

https://www.frontiersin.org/articles/10.3389/frtra.2023.1215182/full

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