Dexamethasone treatment induces the reprogramming of pancreatic acinar cells to hepatocytes and ductal cells.

Dexamethasone treatment induces the reprogramming of pancreatic acinar cells to hepatocytes and ductal cells.

BACKGROUND:The pancreatic exocrine cell line AR42J-B13 can be reprogrammed to hepatocytes following treatment with dexamethasone. The question arises whether dexamethasone also has the capacity to induce ductal cells as well as hepatocytes. METHODOLOGY/PRINCIPAL FINDINGS:AR42J-B13 cells were treated...

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Bibliographic Details
Main Authors: Amani Al-Adsani, Zoë D Burke, Daniel Eberhard, Katherine L Lawrence, Chia-Ning Shen, Anil K Rustgi, Hiroshi Sakaue, J Mark Farrant, David Tosh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2965100?pdf=render

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http://europepmc.org/articles/PMC2965100?pdf=render

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