Natural Trienoic Acids as Anticancer Agents: First Stereoselective Synthesis, Cell Cycle Analysis, Induction of Apoptosis, Cell Signaling and Mitochondrial Targeting Studies

Natural Trienoic Acids as Anticancer Agents: First Stereoselective Synthesis, Cell Cycle Analysis, Induction of Apoptosis, Cell Signaling and Mitochondrial Targeting Studies

The first Z-stereoselective method was developed for the synthesis of unsaturated acids containing a 1Z,5Z,9Z-triene moiety in 61–64% yields using the new Ti-catalyzed cross-coupling of oxygen-containing and aliphatic 1,2-dienes as the key synthetic step. It was shown for the first time that trienoi...

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Bibliographic Details
Main Authors: Vladimir A. D’yakonov, Alexey A. Makarov, Lilya U. Dzhemileva, Ilfir R. Ramazanov, Elina Kh. Makarova, Usein M. Dzhemilev
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
Z,Z,Z-trienoic acids
cross-cyclomagnesiation
topoisomerase inhibitors
anticancer activity
apoptosis
cell signaling
Online Access:https://www.mdpi.com/2072-6694/13/8/1808

Internet

https://www.mdpi.com/2072-6694/13/8/1808

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