Blockage of Autophagic Flux and Induction of Mitochondria Fragmentation by Paroxetine Hydrochloride in Lung Cancer Cells Promotes Apoptosis via the ROS-MAPK Pathway

Blockage of Autophagic Flux and Induction of Mitochondria Fragmentation by Paroxetine Hydrochloride in Lung Cancer Cells Promotes Apoptosis via the ROS-MAPK Pathway

Cancer cells are characterized by malignant proliferation and aberrant metabolism and are thereby liable to the depletion of nutrients and accumulation of metabolic waste. To maintain cellular homeostasis, cancer cells are prone to upregulating the canonical autophagy pathway. Here, we identified pa...

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Bibliographic Details
Main Authors: Kun Wang, Qing Gong, Yujuan Zhan, Bonan Chen, Ting Yin, Yuhua Lu, Yilin Zhang, Huiqi Wang, Junzi Ke, Biaoyan Du, Xiaodong Liu, Jianyong Xiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
paroxetine hydrochloride
lung cancer
autophagy
ROS
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00397/full

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https://www.frontiersin.org/article/10.3389/fcell.2019.00397/full

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