Hair Cell Generation in Cochlear Culture Models Mediated by Novel γ-Secretase Inhibitors

Hair Cell Generation in Cochlear Culture Models Mediated by Novel γ-Secretase Inhibitors

Sensorineural hearing loss is prevalent within society affecting the quality of life of 460 million worldwide. In the majority of cases, this is due to insult or degeneration of mechanosensory hair cells in the cochlea. In adult mammals, hair cell loss is irreversible as sensory cells are not replac...

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Bibliographic Details
Main Authors: Silvia T. Erni, John C. Gill, Carlotta Palaferri, Gabriella Fernandes, Michelle Buri, Katherine Lazarides, Denis Grandgirard, Albert S. B. Edge, Stephen L. Leib, Marta Roccio
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
drug therapy
sensorineural hearing loss
cochlear organoids
hair cell regeneration
Notch signaling
gamma secretase inhibitor
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.710159/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.710159/full

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