Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors

Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors

Summary: N-methyl-D-aspartate (NMDA) receptors are critical for synaptic development and plasticity. While glutamate is the primary agonist, protons can modulate NMDA receptor activity at synapses during vesicle exocytosis by mechanisms that are unknown. We used cryo-electron microscopy to solve the...

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Main Authors: Jin-Bao Zhang, Shenghai Chang, Pan Xu, Miao Miao, Hangjun Wu, Youyi Zhang, Tongtong Zhang, Han Wang, Jilin Zhang, Chun Xie, Nan Song, Cheng Luo, Xing Zhang, Shujia Zhu
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718318473

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http://www.sciencedirect.com/science/article/pii/S2211124718318473

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