A quest for the stereo-electronic requirements for selective agonism for the neurotrophin receptors TrkA and TrkB in 17-spirocyclic-dehydroepiandrosterone derivatives

A quest for the stereo-electronic requirements for selective agonism for the neurotrophin receptors TrkA and TrkB in 17-spirocyclic-dehydroepiandrosterone derivatives

IntroductionThe neurotrophin system plays a pivotal role in the development, morphology, and survival of the nervous system, and its dysregulation has been manifested in numerous neurodegenerative and neuroinflammatory diseases. Neurotrophins NGF and BDNF are major growth factors that prevent neuron...

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Bibliographic Details
Main Authors: Daniele Narducci, Despoina Charou, Thanasis Rogdakis, Ioanna Zota, Vivi Bafiti, Maria Zervou, Theodora Katsila, Achille Gravanis, Kyriakos C. Prousis, Ioannis Charalampopoulos, Theodora Calogeropoulou
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
neurotrophin mimetics
TrkA
TrkB
receptor agonists
signaling
neuroprotection
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1244133/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2023.1244133/full

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