Ketone Body Infusion With 3‐Hydroxybutyrate Reduces Myocardial Glucose Uptake and Increases Blood Flow in Humans: A Positron Emission Tomography Study

Ketone Body Infusion With 3‐Hydroxybutyrate Reduces Myocardial Glucose Uptake and Increases Blood Flow in Humans: A Positron Emission Tomography Study

Background High levels of ketone bodies are associated with improved survival as observed with regular exercise, caloric restriction, and—most recently—treatment with sodium–glucose linked transporter 2 inhibitor antidiabetic drugs. In heart failure, indices of ketone body metabolism are upregulated...

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Bibliographic Details
Main Authors: Lars C. Gormsen, Mads Svart, Henrik Holm Thomsen, Esben Søndergaard, Mikkel H. Vendelbo, Nana Christensen, Lars Poulsen Tolbod, Hendrik Johannes Harms, Roni Nielsen, Henrik Wiggers, Niels Jessen, Jakob Hansen, Hans Erik Bøtker, Niels Møller
Format: Article
Language:English
Published: Wiley 2017-03-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
11C‐palmitate
18F‐fluorodeoxyglucose
cardiac metabolism
hyperketonemia
myocardial glucose uptake
myocardial perfusion
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.116.005066

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https://www.ahajournals.org/doi/10.1161/JAHA.116.005066

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