Disruptin, a cell-penetrating peptide degrader of EGFR

Disruptin, a cell-penetrating peptide degrader of EGFR

Disruptin is a cell-permeable decoy peptide designed to destabilize activated EGFR, both by inhibiting Hsp90 chaperoning and dissociating the active asymmetric EGFR dimer, which leads to an increase in engagement of activated EGFR with the proteolytic degradation machinery and subsequent loss from t...

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Bibliographic Details
Main Authors: Ranjit K. Mehta, Sushmita Shukla, Susmita G. Ramanand, Vishal Somnay, Alexander J. Bridges, Theodore S. Lawrence, Mukesh K. Nyati
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Translational Oncology
Subjects:
HNSCC
Lung Cancer
EGFR
Cell-Penetrating Peptide
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523321001327

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http://www.sciencedirect.com/science/article/pii/S1936523321001327

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