Increased plasma and brain immunoglobulin A in Alzheimer’s disease is lost in apolipoprotein E ε4 carriers

Increased plasma and brain immunoglobulin A in Alzheimer’s disease is lost in apolipoprotein E ε4 carriers

Abstract Background Alzheimer’s disease (AD) is foremost characterized by β-amyloid (Aβ)-extracellular plaques, tau-intraneuronal fibrillary tangles (NFT), and neuroinflammation, but over the last years it has become evident that peripheral inflammation might also contribute to the disease. AD patie...

Full description

Bibliographic Details
Main Authors: Dovilė Pocevičiūtė, Cristina Nuñez-Diaz, Bodil Roth, Shorena Janelidze, The Netherlands Brain Bank, Andreas Giannisis, Oskar Hansson, Malin Wennström
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Alzheimer’s Research & Therapy
Subjects:
Amyloid beta
Blood-brain barrier
Immunoglobulin
Inflammation
Online Access:https://doi.org/10.1186/s13195-022-01062-z

Internet

https://doi.org/10.1186/s13195-022-01062-z

Similar Items