Increased plasma and brain immunoglobulin A in Alzheimer’s disease is lost in apolipoprotein E ε4 carriers

Increased plasma and brain immunoglobulin A in Alzheimer’s disease is lost in apolipoprotein E ε4 carriers

Abstract Background Alzheimer’s disease (AD) is foremost characterized by β-amyloid (Aβ)-extracellular plaques, tau-intraneuronal fibrillary tangles (NFT), and neuroinflammation, but over the last years it has become evident that peripheral inflammation might also contribute to the disease. AD patie...

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Bibliographic Details
Main Authors: Dovilė Pocevičiūtė, Cristina Nuñez-Diaz, Bodil Roth, Shorena Janelidze, The Netherlands Brain Bank, Andreas Giannisis, Oskar Hansson, Malin Wennström
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Alzheimer’s Research & Therapy
Subjects:
Amyloid beta
Blood-brain barrier
Immunoglobulin
Inflammation
Online Access:https://doi.org/10.1186/s13195-022-01062-z

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