HIF-1α and HIF-2α Differently Regulate the Radiation Sensitivity of NSCLC Cells

HIF-1α and HIF-2α Differently Regulate the Radiation Sensitivity of NSCLC Cells

The hypoxia-inducible transcription factors (HIF)-1/2α are the main oxygen sensors which regulate the adaptation to intratumoral hypoxia. The aim of this study was to assess the role of the HIF proteins in regulating the radiation response of a non-small cell lung cancer (NSCLC) in vitro m...

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Bibliographic Details
Main Authors: Eloy Moreno Roig, Arjan J. Groot, Ala Yaromina, Tessa C. Hendrickx, Lydie M. O. Barbeau, Lorena Giuranno, Glenn Dams, Jonathan Ient, Veronica Olivo Pimentel, Marike W. van Gisbergen, Ludwig J. Dubois, Marc A. Vooijs
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Cells
Subjects:
hypoxia
HIF
radiotherapy
metabolism
Online Access:http://www.mdpi.com/2073-4409/8/1/45

Internet

http://www.mdpi.com/2073-4409/8/1/45

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