Discovery and validation of PURA as a transcription target of 20(S)-protopanaxadiol: Implications for the treatment of cognitive dysfunction

Discovery and validation of PURA as a transcription target of 20(S)-protopanaxadiol: Implications for the treatment of cognitive dysfunction

Background: 20(S)-protopanaxadiol (PPD), a ginsenoside metabolite, has prominent benefits for the central nervous system, especially in improving learning and memory. However, its transcriptional targets in brain tissue remain unknown. Methods: In this study, we first used mass spectrometry-based dr...

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Bibliographic Details
Main Authors: Feiyan Chen, Wenjing Zhang, Shuyi Xu, Hantao Zhang, Lin Chen, Cuihua Chen, Zhu Zhu, Yunan Zhao
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Journal of Ginseng Research
Subjects:
Drug affinity responsive target stability
Transcription factors
PURA
20(S)-protopanaxadiol
Cognitive dysfunction
Online Access:http://www.sciencedirect.com/science/article/pii/S1226845323000520

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http://www.sciencedirect.com/science/article/pii/S1226845323000520

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