Genetic variation of FcγRIIa induces higher uptake of Leishmania infantum and modulates cytokine production by adherent mononuclear cells in vitro

Genetic variation of FcγRIIa induces higher uptake of Leishmania infantum and modulates cytokine production by adherent mononuclear cells in vitro

IntroductionSingle nucleotide variations (SNVs) are specific genetic variations that commonly occur in a population and often do not manifest phenotypically. However, depending on their location and the type of nucleotide exchanged, an SNV can alter or inhibit the function of the gene in which it oc...

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Main Authors: Jonatas da Silva Catarino, Rafael Faria de Oliveira, Marcos Vinicius Silva, Helioswilton Sales-Campos, Fernanda Bernadelli de Vito, Djalma Alexandre Alves da Silva, Lucila Langoni Naves, Carlo José Freire Oliveira, Denise Bertulucci Rocha Rodrigues, Virmondes Rodrigues
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Immunology
Subjects:
leishmaniasis
FcγRIIa (CD32a)
polymorphism
AMCs
infection
phagocytosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1343602/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1343602/full

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