Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis

Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic interstitial pneumonia with unknown causes. The incidence rate increases year by year and the prognosis is poor without cure. Recently, phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB/AKT) signaling pathway can be consi...

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Bibliographic Details
Main Authors: Jincheng Wang, Kaili Hu, Xuanyan Cai, Bo Yang, Qiaojun He, Jiajia Wang, Qinjie Weng
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Idiopathic pulmonary fibrosis
PI3K/AKT signaling
Pathogenesis
Coagulation cascade
Immune activation
Fibroblast accumulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521002719

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http://www.sciencedirect.com/science/article/pii/S2211383521002719

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