Therapeutic phosphorodiamidate morpholino oligonucleotides: Physical properties, solution structures, and folding thermodynamics

Therapeutic phosphorodiamidate morpholino oligonucleotides: Physical properties, solution structures, and folding thermodynamics

Elucidating the structure-function relationships for therapeutic RNA mimicking phosphorodiamidate morpholino oligonucleotides (PMOs) is challenging due to the lack of information about their structures. While PMOs have been approved by the US Food and Drug Administration for treatment of Duchenne mu...

Full description

Bibliographic Details
Main Authors: Farkhad Maksudov, Evgenii Kliuchnikov, Daniel Pierson, M.L. Ujwal, Kenneth A. Marx, Arani Chanda, Valeri Barsegov
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Oligonucleotides: Therapies and Applications
phosphorodiamidate morpholino oligomers
circular dichroism
viscosity versus concentration profiles
MD simulations
computational molecular modeling
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253123000276

Internet

http://www.sciencedirect.com/science/article/pii/S2162253123000276

Similar Items