Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model

Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model

Dietary methionine restriction (MR), defined as a reduction of methionine intake by around 80%, has been shown to reproducibly decrease tumor growth and synergize with cancer therapies. In this study, we combined DMR with immune checkpoint inhibitors (ICIs) in a model of colon adenocarcinoma. In vit...

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Bibliographic Details
Main Authors: Lauren C. Morehead, Sarita Garg, Katherine F. Wallis, Camila C. Simoes, Eric R. Siegel, Alan J. Tackett, Isabelle R. Miousse
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Cancers
Subjects:
methionine restriction
immune checkpoint inhibitors
PD-L1
STING
colorectal
Online Access:https://www.mdpi.com/2072-6694/15/18/4467

Internet

https://www.mdpi.com/2072-6694/15/18/4467

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