Branching Ionizable Lipids Can Enhance the Stability, Fusogenicity, and Functional Delivery of mRNA

Branching Ionizable Lipids Can Enhance the Stability, Fusogenicity, and Functional Delivery of mRNA

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Ionizable lipids with branched tails have been used in lipid nanoparticles (LNPs)‐based messenger RNA (mRNA) therapeutics like COVID‐19 vaccines. However, due to the limited commercial availability of branched ingredients, a systematic analysis of how the branched tails affect LNP quality has been l...

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Bibliographic Details
Main Authors: Kazuki Hashiba, Yusuke Sato, Masamitsu Taguchi, Sachiko Sakamoto, Ayaka Otsu, Yoshiki Maeda, Takuya Shishido, Masao Murakawa, Arimichi Okazaki, Hideyoshi Harashima
Format: Article
Language:English
Published: Wiley-VCH 2023-01-01
Series:Small Science
Subjects:
branched tail
genome editing
ionizable lipids
lipid nanoparticles
mRNA
Online Access:https://doi.org/10.1002/smsc.202200071

Internet

https://doi.org/10.1002/smsc.202200071

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