TCF4 trinucleotide repeat expansions and UV irradiation increase susceptibility to ferroptosis in Fuchs endothelial corneal dystrophy

TCF4 trinucleotide repeat expansions and UV irradiation increase susceptibility to ferroptosis in Fuchs endothelial corneal dystrophy

Fuchs endothelial corneal dystrophy (FECD), the leading indication for corneal transplantation in the U.S., causes loss of corneal endothelial cells (CECs) and corneal edema leading to vision loss. FECD pathogenesis is linked to impaired response to oxidative stress and environmental ultraviolet A (...

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Bibliographic Details
Main Authors: Sanjib Saha, Jessica M. Skeie, Gregory A. Schmidt, Tim Eggleston, Hanna Shevalye, Christopher S. Sales, Pornpoj Phruttiwanichakun, Apurva Dusane, Matthew G. Field, Tommy A. Rinkoski, Michael P. Fautsch, Keith H. Baratz, Madhuparna Roy, Albert S. Jun, Chandler Pendleton, Aliasger K. Salem, Mark A. Greiner
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Redox Biology
Subjects:
Corneal endothelium
Corneal transplant
Ferritin
Ferroptosis
Ferrous iron
Fuchs endothelial corneal dystrophy
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724003264

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http://www.sciencedirect.com/science/article/pii/S2213231724003264

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