Emerging role of sirtuins on tumorigenesis: possible link between aging and cancer
Aging is the strongest risk factor for cancer development,suggesting that molecular crosstalks between aging andtumorigenesis exist in many cellular pathways. Recently,Sirtuins (Sirt1-7), the mammalian homologues of aging-relatedsir2α in yeast, have been shown to modulate several majorcellular pathw...
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| Format: | Article |
| Language: | English |
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Korean Society for Biochemistry and Molecular Biology
2013-09-01
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| Series: | BMB Reports |
| Subjects: | |
| Online Access: | http://bmbreports.org/jbmb/pdf.php?data=MTMxMDA3MTZAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0Ni05JTVEMTMwOTI2MTcxN18lMjg0MjktNDM4JTI5Qk1CXzEzLTE4MC5wZGY= |
| _version_ | 1828427056085467136 |
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| author | Yong I. Cha Hyun-Seok Kim |
| author_facet | Yong I. Cha Hyun-Seok Kim |
| author_sort | Yong I. Cha |
| collection | DOAJ |
| description | Aging is the strongest risk factor for cancer development,suggesting that molecular crosstalks between aging andtumorigenesis exist in many cellular pathways. Recently,Sirtuins (Sirt1-7), the mammalian homologues of aging-relatedsir2α in yeast, have been shown to modulate several majorcellular pathways, such as DNA repair, inflammation,metabolism, cell death, and proliferation in response todiverse stresses, and may serve as a possible molecular linkbetween aging and tumorignenesis. In addition, growingevidence suggests that sirtuins are directly implicated in thedevelopment of cancer, and they can act as either a tumorsuppressor or promoter, depending on the cellular context andtumor types. While the functions of Sirt1 in tumorigenesishave been reported and reviewed in many studies, theconnection between sirtuins 2-7 and the development ofcancer is less established. Thus, this review will present therecent updates on the emerging roles of Sirt2-7 members incarcinogenesis. [BMB Reports 2013; 46(9): 429-438] |
| first_indexed | 2024-12-10T16:54:33Z |
| format | Article |
| id | doaj.art-a597b20d7c5f4854be89bbd3c45455f7 |
| institution | Directory Open Access Journal |
| issn | 1976-6696 1976-670X |
| language | English |
| last_indexed | 2024-12-10T16:54:33Z |
| publishDate | 2013-09-01 |
| publisher | Korean Society for Biochemistry and Molecular Biology |
| record_format | Article |
| series | BMB Reports |
| spelling | doaj.art-a597b20d7c5f4854be89bbd3c45455f72022-12-22T01:40:46ZengKorean Society for Biochemistry and Molecular BiologyBMB Reports1976-66961976-670X2013-09-01469429438http://dx.doi.org/10.5483/BMBRep.2013.46.9.180Emerging role of sirtuins on tumorigenesis: possible link between aging and cancerYong I. ChaHyun-Seok KimAging is the strongest risk factor for cancer development,suggesting that molecular crosstalks between aging andtumorigenesis exist in many cellular pathways. Recently,Sirtuins (Sirt1-7), the mammalian homologues of aging-relatedsir2α in yeast, have been shown to modulate several majorcellular pathways, such as DNA repair, inflammation,metabolism, cell death, and proliferation in response todiverse stresses, and may serve as a possible molecular linkbetween aging and tumorignenesis. In addition, growingevidence suggests that sirtuins are directly implicated in thedevelopment of cancer, and they can act as either a tumorsuppressor or promoter, depending on the cellular context andtumor types. While the functions of Sirt1 in tumorigenesishave been reported and reviewed in many studies, theconnection between sirtuins 2-7 and the development ofcancer is less established. Thus, this review will present therecent updates on the emerging roles of Sirt2-7 members incarcinogenesis. [BMB Reports 2013; 46(9): 429-438]http://bmbreports.org/jbmb/pdf.php?data=MTMxMDA3MTZAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0Ni05JTVEMTMwOTI2MTcxN18lMjg0MjktNDM4JTI5Qk1CXzEzLTE4MC5wZGY=AcetylationAgingDeacetylaseSirtuinTumorigenesis |
| spellingShingle | Yong I. Cha Hyun-Seok Kim Emerging role of sirtuins on tumorigenesis: possible link between aging and cancer BMB Reports Acetylation Aging Deacetylase Sirtuin Tumorigenesis |
| title | Emerging role of sirtuins on tumorigenesis: possible link between aging and cancer |
| title_full | Emerging role of sirtuins on tumorigenesis: possible link between aging and cancer |
| title_fullStr | Emerging role of sirtuins on tumorigenesis: possible link between aging and cancer |
| title_full_unstemmed | Emerging role of sirtuins on tumorigenesis: possible link between aging and cancer |
| title_short | Emerging role of sirtuins on tumorigenesis: possible link between aging and cancer |
| title_sort | emerging role of sirtuins on tumorigenesis possible link between aging and cancer |
| topic | Acetylation Aging Deacetylase Sirtuin Tumorigenesis |
| url | http://bmbreports.org/jbmb/pdf.php?data=MTMxMDA3MTZAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0Ni05JTVEMTMwOTI2MTcxN18lMjg0MjktNDM4JTI5Qk1CXzEzLTE4MC5wZGY= |
| work_keys_str_mv | AT yongicha emergingroleofsirtuinsontumorigenesispossiblelinkbetweenagingandcancer AT hyunseokkim emergingroleofsirtuinsontumorigenesispossiblelinkbetweenagingandcancer |