Immune landscape and prognostic immune-related genes in KRAS-mutant colorectal cancer patients

Immune landscape and prognostic immune-related genes in KRAS-mutant colorectal cancer patients

Abstract Background KRAS gene is the most common type of mutation reported in colorectal cancer (CRC). KRAS mutation-mediated regulation of immunophenotype and immune pathways in CRC remains to be elucidated. Methods 535 CRC patients were used to compare the expression of immune-related genes (IRGs)...

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Bibliographic Details
Main Authors: Jungang Liu, Xiaoliang Huang, Haizhou Liu, Chunyin Wei, Haiming Ru, Haiquan Qin, Hao Lai, Yongsheng Meng, Guo Wu, Weishun Xie, Xianwei Mo, Caroline H. Johnson, Yawei Zhang, Weizhong Tang
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Translational Medicine
Subjects:
Colorectal cancer
Tumor-infiltrating immune cells
Immunosuppression
KRAS mutation
Online Access:https://doi.org/10.1186/s12967-020-02638-9

Internet

https://doi.org/10.1186/s12967-020-02638-9

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