The Desmosome-Keratin Scaffold Integrates ErbB Family and Mechanical Signaling to Polarize Epidermal Structure and Function

The Desmosome-Keratin Scaffold Integrates ErbB Family and Mechanical Signaling to Polarize Epidermal Structure and Function

While classic cadherin-actin connections in adherens junctions (AJs) have ancient origins, intermediate filament (IF) linkages with desmosomal cadherins arose in vertebrate organisms. In this mini-review, we discuss how overlaying the IF-desmosome network onto the existing cadherin-actin network pro...

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Bibliographic Details
Main Authors: Kathleen J. Green, Carien M. Niessen, Matthias Rübsam, Bethany E. Perez White, Joshua A. Broussard
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
epidermal polarity
desmoglein
intermediate filament
EGFR signaling
actin cytoskeleton
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.903696/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.903696/full

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