FMRP activity and control of Csw/SHP2 translation regulate MAPK-dependent synaptic transmission

FMRP activity and control of Csw/SHP2 translation regulate MAPK-dependent synaptic transmission

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Noonan syndrome (NS) and NS with multiple lentigines (NSML) cognitive dysfunction are linked to SH2 domain-containing protein tyrosine phosphatase-2 (SHP2) gain-of-function (GoF) and loss-of-function (LoF), respectively. In Drosophila disease models, we find both SHP2 mutations from human patients a...

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Bibliographic Details
Main Authors: Shannon N. Leahy, Chunzhu Song, Dominic J. Vita, Kendal Broadie
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879533/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879533/?tool=EBI

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