Chronic Mild Stress and Venlafaxine Treatment Were Associated with Altered Expression Level and Methylation Status of New Candidate Inflammatory Genes in PBMCs and Brain Structures of Wistar Rats

Chronic Mild Stress and Venlafaxine Treatment Were Associated with Altered Expression Level and Methylation Status of New Candidate Inflammatory Genes in PBMCs and Brain Structures of Wistar Rats

Preclinical studies conducted to date suggest that depression could be elicited by the elevated expression of proinflammatory molecules: these play a key role in the mediation of neurochemical, neuroendocrine and behavioral changes. Thus, this study investigates the effect of chronic mild stress (CM...

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Bibliographic Details
Main Authors: Katarzyna Bialek, Piotr Czarny, Paulina Wigner, Ewelina Synowiec, Gabriela Barszczewska, Michal Bijak, Janusz Szemraj, Monika Niemczyk, Katarzyna Tota-Glowczyk, Mariusz Papp, Tomasz Sliwinski
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Genes
Subjects:
depression
chronic mild stress
venlafaxine
inflammation
expression
methylation
Online Access:https://www.mdpi.com/2073-4425/12/5/667

Internet

https://www.mdpi.com/2073-4425/12/5/667

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