FGF9 Recruits β‐Catenin to Increase Hepatic ECM Synthesis and Promote NASH‐Driven HCC

FGF9 Recruits β‐Catenin to Increase Hepatic ECM Synthesis and Promote NASH‐Driven HCC

Abstract Most nonalcoholic steatohepatitis (NASH) patients develop severe fibrosis through extracellular matrix (ECM) accumulation, which can lead to hepatocellular carcinoma (HCC). Fibroblast growth factor 9 (FGF9) is involved in serial types of cancer; however, the specific role of FGF9 in NASH‐dr...

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Bibliographic Details
Main Authors: Lei Zhang, Qing Zhang, Da Teng, Manyu Guo, Kechao Tang, Zhenglin Wang, Xiang Wei, Li Lin, Xiaomin Zhang, Xiuyun Wang, Dake Huang, Cuiping Ren, Qingsong Yang, Wenjun Zhang, Yong Gao, Wei Chen, Yongsheng Chang, Huabing Zhang
Format: Article
Language:English
Published: Wiley 2023-10-01
Series:Advanced Science
Subjects:
extracellular matrix
FGF9
liver cancer
NASH
β‐catenin
Online Access:https://doi.org/10.1002/advs.202301166

Internet

https://doi.org/10.1002/advs.202301166

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