Preclinical-to-clinical Anti-cancer Drug Response Prediction and Biomarker Identification Using TINDL

Preclinical-to-clinical Anti-cancer Drug Response Prediction and Biomarker Identification Using TINDL

Prediction of the response of cancer patients to different treatments and identification of biomarkers of drug response are two major goals of individualized medicine. Here, we developed a deep learning framework called TINDL, completely trained on preclinical cancer cell lines (CCLs), to predict th...

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Bibliographic Details
Main Authors: David Earl Hostallero, Lixuan Wei, Liewei Wang, Junmei Cairns, Amin Emad
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Genomics, Proteomics & Bioinformatics
Subjects:
Drug response
Deep learning
Explainable AI
Cancer
Gene knockdown experiment
Online Access:http://www.sciencedirect.com/science/article/pii/S1672022923000323

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http://www.sciencedirect.com/science/article/pii/S1672022923000323

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