Tripling the Bioavailability of Rosuvastatin Calcium Through Development and Optimization of an In-Situ Forming Nanovesicular System

Tripling the Bioavailability of Rosuvastatin Calcium Through Development and Optimization of an In-Situ Forming Nanovesicular System

In situ forming nanovesicular systems (IFNs) were prepared and optimized to improve Rosuvastatin calcium (RC) oral bioavailability through increasing its solubility and dissolution rate. The IFN was composed of Tween<sup>&#174;</sup> 80 (T80), cetyl alcohol (CA), in addition to manni...

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Bibliographic Details
Main Authors: Ibrahim Elsayed, Rania Moataz El-Dahmy, Ahmed Hassen Elshafeey, Nabaweya Abdelaziz Abd El Gawad, Omaima Naim El Gazayerly
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Pharmaceutics
Subjects:
in situ
Rosuvastatin calcium
bioavailability enhancement
mannitol and Aerosil
Online Access:https://www.mdpi.com/1999-4923/11/6/275

Internet

https://www.mdpi.com/1999-4923/11/6/275

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