Design, Synthesis and Biological Evaluation of Novel Pleuromutilin Derivatives Containing 6-Chloro-1-R-1<i>H</i>-pyrazolo[3,4-<i>d</i>]pyrimidine-4-amino Side Chain

Design, Synthesis and Biological Evaluation of Novel Pleuromutilin Derivatives Containing 6-Chloro-1-R-1<i>H</i>-pyrazolo[3,4-<i>d</i>]pyrimidine-4-amino Side Chain

Two series of pleuromutilin derivatives were designed and synthesized as inhibitors against <i>Staphylococcus aureus</i> (<i>S. aureus</i>). 6-chloro-4-amino-1-R-1<i>H</i>-pyrazolo[3,4<i>-d</i>]pyrimidine or 4-(6-chloro-1-R-1<i>H</i>-pyrazo...

Full description

Bibliographic Details
Main Authors: Jun Wang, Yu-Han Hu, Ke-Xin Zhou, Wei Wang, Fei Li, Ke Li, Guang-Yu Zhang, You-Zhi Tang
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Molecules
Subjects:
antibacterial activity
MRSA
pleuromutilin
1<i>H</i>-pyrazolo[3,4-<i>d</i>]pyrimidine
Online Access:https://www.mdpi.com/1420-3049/28/9/3975

Internet

https://www.mdpi.com/1420-3049/28/9/3975

Similar Items