Essential role of Mg2+ in mouse preimplantation embryo development revealed by TRPM7 chanzyme-deficient gametes

Essential role of Mg2+ in mouse preimplantation embryo development revealed by TRPM7 chanzyme-deficient gametes

Summary: TRPM7 (transient receptor potential cation channel subfamily M member 7) is a chanzyme with channel and kinase domains essential for embryo development. Using gamete-specific Trpm7-null lines, we report that TRPM7-mediated Mg2+ influx is indispensable for reaching the blastocyst stage. TRPM...

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Bibliographic Details
Main Authors: Neha Gupta, Cristina Soriano-Úbeda, Paula Stein, Virginia Savy, Brian N. Papas, Goli Ardestani, Ingrid Carvacho, Dominique Alfandari, Carmen J. Williams, Rafael A. Fissore
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Cell Reports
Subjects:
CP: Developmental biology
CP: Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723012445

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http://www.sciencedirect.com/science/article/pii/S2211124723012445

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