| Summary: | Custard apple (<i>Annona cherimola</i> Mill.) is a tropical fruit source of bioactive compounds whose main producer worldwide is Andalusia, Spain. Because of its processing, the food industry generates large amounts of by-products, such as peels and seeds. These by-products are rich in phenolic compounds with high antioxidant, anti-inflammatory and anti-aging powers. The objective of this work is to evaluate, by different <i>in vitro</i> methods, the antioxidant and anti-inflammatory potential of cherimoya by-products rich in phenolic compounds for the development of cosmeceuticals. In addition, the major phenolic compounds present in the custard apple peel and seed samples were characterized by HPLC-ESI-QTOF-MS. The results showed that both the peel and seed of custard apple have a strong potential against oxidative stress and inflammation. Its phytochemical profile due to the presence of phenolic compounds (catechin, epicatechin, rutin, quinic acid, vanillic acid, etc.) makes both industrial by-products attractive bioactive ingredients for the manufacture of functional food and cosmeceuticals.
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