High cyclin E1 protein, but not gene amplification, is prognostic for basal‐like breast cancer

High cyclin E1 protein, but not gene amplification, is prognostic for basal‐like breast cancer

Abstract Basal‐like breast cancer (BLBC) has a greater overlap in molecular features with high‐grade serous ovarian cancer (HGSOC) than with other breast cancer subtypes. Similarities include BRCA1 mutation, high frequency of TP53 mutation, and amplification of CCNE1 (encoding the cyclin E1 protein)...

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Bibliographic Details
Main Authors: Diar Aziz, Christine Lee, Venessa Chin, Kristine J Fernandez, Zoe Phan, kConFab Investigators, AOCS Study Group, Paul Waring, C Elizabeth Caldon
Format: Article
Language:English
Published: Wiley 2022-07-01
Series:The Journal of Pathology: Clinical Research
Subjects:
cyclin E1
CCNE1 amplification
19q12
basal‐like breast cancer
high‐grade serous ovarian cancer
homologous recombination deficiency
Online Access:https://doi.org/10.1002/cjp2.269

Internet

https://doi.org/10.1002/cjp2.269

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