Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer’s disease

Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer’s disease

Abstract Background Microglial activation is one hallmark of Alzheimer disease (AD) neuropathology but the impact of the regional interplay of microglia cells in the brain is poorly understood. We hypothesized that microglial activation is regionally synchronized in the healthy brain but experiences...

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Bibliographic Details
Main Authors: Artem Zatcepin, Johannes Gnörich, Boris-Stephan Rauchmann, Laura M. Bartos, Stephan Wagner, Nicolai Franzmeier, Maura Malpetti, Xianyuan Xiang, Yuan Shi, Samira Parhizkar, Maximilian Grosch, Karin Wind-Mark, Sebastian T. Kunte, Leonie Beyer, Carolin Meyer, Desirée Brösamle, Ann-Christin Wendeln, Collins Osei-Sarpong, Steffanie Heindl, Arthur Liesz, Sophia Stoecklein, Gloria Biechele, Anika Finze, Florian Eckenweber, Simon Lindner, Axel Rominger, Peter Bartenstein, Michael Willem, Sabina Tahirovic, Jochen Herms, Katharina Buerger, Mikael Simons, Christian Haass, Rainer Rupprecht, Markus J. Riemenschneider, Nathalie L. Albert, Marc Beyer, Jonas J. Neher, Lars Paeger, Johannes Levin, Günter U. Höglinger, Robert Perneczky, Sibylle I. Ziegler, Matthias Brendel
Format: Article
Language:English
Published: BMC 2024-09-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease
Dementia
Microglia
Neuroinflammation
TSPO
PET
Online Access:https://doi.org/10.1186/s13024-024-00752-6

Internet

https://doi.org/10.1186/s13024-024-00752-6

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