Trichostatin D as a Novel KLF2 Activator Attenuates TNFα-Induced Endothelial Inflammation

Trichostatin D as a Novel KLF2 Activator Attenuates TNFα-Induced Endothelial Inflammation

Krüppel-like factor 2 (KLF2) is an atherosclerotic protective transcription factor that maintains endothelial cell homeostasis through its anti-inflammatory, anti-oxidant, and antithrombotic properties. The aim of this study was to discover KLF2 activators from microbial secondary metabolites and ex...

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Bibliographic Details
Main Authors: Lijuan Lei, Minghua Chen, Chenyin Wang, Xinhai Jiang, Yinghong Li, Weizhi Wang, Shunwang Li, Liping Zhao, Ren Sheng, Jiangxue Han, Yuyan Zhang, Yuchuan Chen, Biying Yan, Yexiang Wu, Liyan Yu, Shuyi Si, Yanni Xu
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
trichostatin D
KLF2
endothelial inflammation
atherosclerosis
HDAC
NLRP3
Online Access:https://www.mdpi.com/1422-0067/23/21/13477

Internet

https://www.mdpi.com/1422-0067/23/21/13477

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