Design, Synthesis, Antimycobacterial Evaluation, and In Silico Studies of 3-(Phenylcarbamoyl)-pyrazine-2-carboxylic Acids

Design, Synthesis, Antimycobacterial Evaluation, and In Silico Studies of 3-(Phenylcarbamoyl)-pyrazine-2-carboxylic Acids

Pyrazinamide, the first-line antitubercular drug, has been regarded the basic component of tuberculosis treatment for over sixty years. Researchers have investigated its effect on Mycobacterium tuberculosis for this long time, and as a result, new potential targets of pyrazinamide or its active form...

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Bibliographic Details
Main Authors: Lucia Semelková, Petra Janošcová, Carlos Fernandes, Ghada Bouz, Ondřej Janďourek, Klára Konečná, Pavla Paterová, Lucie Navrátilová, Jiří Kuneš, Martin Doležal, Jan Zitko
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:Molecules
Subjects:
anilides
antimycobacterial activity
cytotoxicity
DprE1
pyrazinamide
pyrazinoic acid
RpsA
Online Access:https://www.mdpi.com/1420-3049/22/9/1491

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https://www.mdpi.com/1420-3049/22/9/1491

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