PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model

PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model

Summary: Protocadherins (PCDHs) are cell adhesion molecules that regulate many essential neurodevelopmental processes related to neuronal maturation, dendritic arbor formation, axon pathfinding, and synaptic plasticity. Biallelic loss-of-function variants in PCDH12 are associated with several neurod...

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Bibliographic Details
Main Authors: Jennifer Rakotomamonjy, Lauren Rylaarsdam, Lucas Fares-Taie, Sean McDermott, Devin Davies, George Yang, Fikayo Fagbemi, Maya Epstein, Martín Fairbanks-Santana, Jean-Michel Rozet, Alicia Guemez-Gamboa
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Cell Reports
Subjects:
CP: Developmental biology
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723008562

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http://www.sciencedirect.com/science/article/pii/S2211124723008562

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