NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte

NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte

Hepatocellular carcinoma (HCC) is a deadly human cancer associated with chronic inflammation. The cytosolic pathogen sensor NLRP12 has emerged as a negative regulator of inflammation, but its role in HCC is unknown. Here we investigated the role of NLRP12 in HCC using mouse models of HCC induced by...

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Bibliographic Details
Main Authors: SM Nashir Udden, Youn-Tae Kwak, Victoria Godfrey, Md Abdul Wadud Khan, Shahanshah Khan, Nicolas Loof, Lan Peng, Hao Zhu, Hasan Zaki
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-04-01
Series:eLife
Subjects:
hepatocellular carcinoma
NOD-like receptors
NLRP12
inflammation
JNK
hepatocyte
Online Access:https://elifesciences.org/articles/40396

Internet

https://elifesciences.org/articles/40396

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